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Target intelligence / Profile preview
Casein Kinase II Alpha Subunit (CK2A1)
- Target
- CK2A1
- Molecular classification
- Enzyme, Serine/threonine protein kinase, Protein Kinase
01
Overview
Casein kinase II alpha subunit (CK2A1) is the catalytic alpha subunit of casein kinase II, a serine/threonine protein kinase. It plays a central role in regulating numerous cellular processes, including cell cycle progression, apoptosis, and transcriptional regulation. CK2 is constitutively active and its deregulation has been linked to tumorigenesis.
- Other names
- Casein kinase II subunit alphaCSNK2A1
02
Mechanism of action
CX-4945 blocks enzymatic activity of CK2A1 and affects calcium signaling between ER and mitochondria.
03
Biological functions
Cell cycle progressionApoptosisTranscriptional regulationViral infection responseMitochondrial homeostasisMitophagyCalcium signalingCell proliferationDNA repairCircadian rhythm regulationStress responses
04
Disease associations
CancerTumorigenesis
05
Safety considerations
Essentiality for cell survival makes complete inhibition challenging.
06
Interacting drugs
CX-4945
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