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Target intelligence / Profile preview
Casein Kinase II Subunit Alpha (CK2α)
- Target
- CK2α
- Molecular classification
- Enzyme, Serine/threonine protein kinase
01
Overview
Casein kinase II subunit alpha (CK2α) is the catalytic subunit of casein kinase 2 (CK2), a highly conserved and ubiquitously expressed serine/threonine protein kinase. CK2 is involved in phosphorylating acidic proteins such as casein and plays a critical role in various cellular processes including cell cycle control, DNA repair, circadian rhythm regulation, and cell survival. Deregulation or overexpression of CK2 has been linked to tumorigenesis. Its anti-apoptotic properties may allow mutated cells to evade programmed cell death pathways contributing to cancer development.
- Other names
- CSNK2A1
02
Mechanism of action
Inhibition of CK2 kinase activity
03
Biological functions
Cell cycle controlDNA repairApoptosis regulationCell survivalCircadian rhythm regulationProtein phosphorylation
04
Disease associations
CancerTumorigenesis
05
Safety considerations
Essential for cell viability; complete inhibition may be toxic
06
Interacting drugs
SGC-CK2-1
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