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Target intelligence / Profile preview
Casein phosphopeptide-amorphous calcium phosphate complex (CPP-ACP)
- Target
- CPP-ACP
- Molecular classification
- Multiprotein complex, Nanocomplex, Biomineralization agent
01
Overview
The **casein phosphopeptide-amorphous calcium phosphate complex (CPP-ACP)** is a nano-sized aggregate formed from tryptic digestion of casein milk proteins, yielding phosphopeptides that stabilize calcium and phosphate ions in an amorphous, highly bioavailable structure[1][2][4]. CPP-ACP is used in dental and nutritional products to promote enamel remineralization and intestinal calcium absorption by preventing mineral precipitation and facilitating uptake[1][2][4][5]. While extensively studied for dental caries prevention and as a supplement for bone health, the complex is not a classical molecular target in drug discovery but a bioactive ingredient or delivery vehicle in food and dental science[5][7]. The composition, typically derived from bovine milk, makes it suitable for most populations, with research supporting its role in enhancing mineral bioavailability and remineralization processes in vivo[4][5][7].
- Other names
- CPP-ACPCasein phosphopeptide-amorphous calcium phosphate nanocomplexRecaldentTooth Mousse
02
Mechanism of action
Mineral ion stabilization and delivery via peptide binding
03
Biological functions
Mineral stabilization/deliveryEnamel remineralizationCalcium absorptionOsteogenic support
04
Disease associations
Dental cariesOsteoporosis/osteopenia
05
Safety considerations
Allergenicity (milk protein)
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