Target intelligence / Profile preview

Casitas B-lineage lymphoma protein-b (Cbl-b)

Target: Cbl-b
Molecular classification: Enzyme, E3 Ubiquitin Ligase

Overview

Casitas B-lineage lymphoma protein-b (Cbl-b) is an E3 ubiquitin-protein ligase that plays a central role in regulating immune cell activation and maintaining immune homeostasis. It functions as a negative regulator in both innate and adaptive immunity by targeting specific signaling proteins for ubiquitination and subsequent degradation or functional modification. Inhibition of Cbl-b is being explored as a strategy for cancer immunotherapy.

Other names: E3 ubiquitin-protein ligase CBL-BCBLB

Mechanism of action

Inhibition of E3 ubiquitin ligase activity leading to enhanced immune cell activation, particularly T cell activation.

Biological functions

Immune responseRegulation of immune cell activationRegulation of lymphocyte activation thresholdsUbiquitinationProtein degradationSignal transduction

Disease associations

CancerAutoimmune diseaseImmunosuppression

Safety considerations

Potential for autoimmunity if Cbl-b inhibition is not carefully controlled.

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