Target intelligence / Profile preview

Casitas B-lineage Lymphoma Proto-oncogene B (Cbl-b)

Target: Cbl-b
Molecular classification: E3 Ubiquitin-protein Ligase, Enzyme

Overview

Cbl-b is an E3 ubiquitin-protein ligase that acts as a negative regulator of immune cell activation, particularly in T cells and B cells. It controls ligand-induced down-modulation of the T cell receptor (TCR) and regulates signaling through the B cell receptor (BCR). As an E3 ubiquitin ligase, it targets key signaling molecules for ubiquitination-mediated degradation or signal attenuation. Targeting/inhibiting Cbl-b has emerged as a promising strategy for cancer immunotherapy.

Other names: CBLBE3 ubiquitin-protein ligase CBLB

Mechanism of action

Ubiquitination-mediated downregulation/degradation of target proteins

Biological functions

Immune responseNegative regulation of immune cell activationUbiquitinationSignal transduction

Disease associations

CancerAutoimmune diseases

Safety considerations

Heightened immune responses leading to autoimmunity (with deficiency/mutation)Impaired anti-tumor immunity (with gain-of-function)

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