Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Casitas B-lineage lymphoma proto-oncogene-b protein (Cbl-b)
- Target
- Cbl-b
- Molecular classification
- Enzyme, E3 ubiquitin ligase, RING-type E3 ubiquitin ligase
01
Overview
Casitas B-lineage lymphoma proto-oncogene-b protein (Cbl-b) is an E3 ubiquitin-protein ligase that negatively regulates immune cell activation and tolerance. It functions by ubiquitinating target proteins, often leading to their degradation or altered function. Cbl-b plays a critical role in setting thresholds for T-cell activation and maintaining the balance between immunity and tolerance. Dysregulation of Cbl-b is implicated in autoimmune diseases, cancer, and infections, making it a potential therapeutic target for immunomodulation.
- Other names
- E3 ubiquitin-protein ligase CBL-B
02
Mechanism of action
Inhibition of Cbl-b to enhance anti-tumor immunity or modulation for autoimmune disorders/infections.
03
Biological functions
UbiquitinationRegulation of immune cell activationNegative regulation of T-cell activationMaintenance of immune toleranceRegulation of receptor signaling
04
Disease associations
Autoimmune diseasesCancerAllergic diseasesInfections
05
Safety considerations
Increased risk of autoimmunity with inhibition.Potential for allergic reactions or increased susceptibility to infection with modulation.
Beyond the preview
Go deeper on Casitas B-lineage lymphoma proto-oncogene-b protein (Cbl-b).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Casitas B-lineage lymphoma proto-oncogene-b protein (Cbl-b).