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CASK antisense RNA 1 (CASK-AS1)
- Target
- CASK-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA, Non-protein coding RNA
01
Overview
CASK antisense RNA 1 (CASK-AS1) is a long non-coding RNA transcribed from the antisense strand opposite the CASK gene locus. As a member of the antisense lncRNA family, CASK-AS1 is believed to be involved in the regulation of gene expression, particularly affecting its sense gene, CASK, which encodes a multi-domain scaffolding protein implicated in neurodevelopment and synaptic function. Although aberrant lncRNA expression is broadly linked with various human diseases, specific functional or therapeutic relevance for CASK-AS1 is not well-established. It is mainly studied as a regulatory RNA with disease associations based on linked protein-coding genes, not as a drug target itself.
- Other names
- CASK-AS1HGNC:40126NCBI Gene:100873928Ensembl:ENSG00000233033
02
Biological functions
Regulation of gene expression (especially regulation of CASK gene through antisense mechanisms)Possible involvement in neurodevelopmental pathways by regulating CASK (inferred from disease associations, but not definitively established)
03
Disease associations
Intellectual developmental disorder with microcephaly and pontine and cerebellar hypoplasia (associated, not causative)FG syndrome 4 (associated, not causative)Other neurological disorders (as inferred from CASK association)
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