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Target intelligence / Profile preview
Caspase-10 (CASP10)
- Target
- CASP10
- Molecular classification
- Enzyme, Cysteine-aspartic acid protease, Caspase
01
Overview
Caspase-10 is a cysteine-aspartic acid protease (caspase) enzyme that plays a critical role in the extrinsic (death receptor-mediated) apoptosis pathway. It is an initiator caspase activated by death signals, leading to the activation of downstream effector caspases and ultimately cell death. Defects in CASP10 are associated with autoimmune lymphoproliferative syndrome type IIa and may play a role in other diseases.
- Other names
- CASP-10APO2L-R2Mch4
02
Mechanism of action
Proteolytic cleavage and activation of downstream effector caspases (e.g., caspase-3, caspase-7) leading to apoptosis.
03
Biological functions
ApoptosisSignal transductionImmune system regulationLymphocyte homeostasisActivation of effector caspases
04
Disease associations
Autoimmune Lymphoproliferative Syndrome Type IIaLymphomaCancer (potential role in apoptosis evasion)
05
Safety considerations
Potential for off-target effects on other caspases.Dysregulation of apoptosis can lead to unintended consequences.
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