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Target intelligence / Profile preview
Caspase-2 (CASP2)
- Target
- CASP2
- Molecular classification
- Enzyme, Cysteine-aspartic protease, Caspase
01
Overview
Caspase-2 is a highly conserved member of the caspase family of cysteine proteases. It functions as an initiator caspase in apoptosis and has non-apoptotic roles in tumor suppression, cell cycle regulation, DNA repair, and metabolic homeostasis. It is implicated in diseases such as cancer, neurodegeneration (Alzheimer's disease), liver disease, and neurodevelopmental disorders.
02
Mechanism of action
Inhibition of Caspase-2 activity
03
Biological functions
Apoptosis initiationApoptosis executionTumor suppressionCell cycle regulationDNA repairMetabolic homeostasis
04
Disease associations
CancerNeurodegenerative diseaseAlzheimer's diseaseLiver diseaseNeurodevelopmental disorders
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