Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Caspase-3 (CASP3)
- Target
- CASP3
- Molecular classification
- Enzyme, Caspase, Cysteine-aspartic acid protease
01
Overview
Caspase-3 is a crucial cysteine-aspartic acid protease (caspase) that plays a central role in the execution phase of apoptosis, or programmed cell death. It is encoded by the CASP3 gene. Caspase-3 acts as an "executioner" caspase, responsible for dismantling cellular components during apoptosis, leading to chromatin condensation, DNA fragmentation, and formation of apoptotic bodies. Activation occurs via proteolytic cleavage at specific aspartic acid residues by initiator caspases. Elevated levels or fragments can serve as biomarkers in diseases like cancer, neurodegeneration and cardiovascular events.
- Other names
- CPP32YAMAApopain
02
Mechanism of action
Caspase-3 inhibitors block the execution phase of apoptosis by preventing the cleavage of downstream substrates.
03
Biological functions
ApoptosisCell deathChromatin condensationDNA fragmentation
04
Disease associations
CancerNeurodegenerative diseaseCardiovascular disease
05
Safety considerations
Inhibition of caspase-3 may disrupt normal apoptotic processes.Off-target effects of caspase-3 inhibitors could lead to unintended consequences.
06
Biomarkers
Elevated caspase-3 levels or fragments (e.g., p17 fragment) indicate apoptosisCaspase-3 activity as a marker of treatment responseCaspase-3 activation for myocardial infarction diagnosis
Beyond the preview
Go deeper on Caspase-3 (CASP3).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Caspase-3 (CASP3).