Caspase 3 pseudogene 1 (CASP3P1)

Caspase 3 pseudogene 1 (CASP3P1) is classified as a pseudogene, an inactive genomic DNA sequence similar to the functional caspase 3 (CASP3) gene but incapable of producing a functional protein product[4]. In contrast to the true caspase 3 enzyme—which is a critical executioner protease in the apoptotic pathway and a target of drug discovery—CASP3P1 has no known protein-coding function or therapeutically relevant activity. There is no evidence that CASP3P1 is involved in disease, serves as a biomarker, or interacts with any drugs. Its biological relevance, if any, would be indirect, such as effects via non-coding RNA regulation, for which there is currently no published evidence specific to CASP3P1[4]. Note on correctness: The query refers to a pseudogene, not the functional caspase 3 enzyme (CASP3). Pseudogenes are not considered therapeutic targets unless there is exceptional evidence for a functional role—which is lacking for CASP3P1[4]. References to further distinguish from the functional target: - Functional caspase-3 (CASP3) is an executioner caspase essential to apoptosis[1][2]. - CASP3 is a drug target; CASP3P1, by contrast, has no such role[4].

Other names

Caspase 3, apoptosis-related cysteine peptidase pseudogene 1CASP3P1