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Caspase-4
- Molecular classification
- Enzyme, Cysteine-aspartic acid protease, Caspase
01
Overview
Caspase-4 is a human enzyme belonging to the caspase family of cysteine-aspartic acid proteases. It functions as an effector in the non-canonical inflammasome pathway, mediating LPS-induced pyroptosis. Upon activation by cytosolic LPS, it cleaves gasdermin-D and processes pro-inflammatory cytokines. It plays a critical role in innate immunity against Gram-negative bacterial infections, but dysregulation can contribute to pathological inflammation. It is primarily localized to the endoplasmic reticulum membrane. Inhibitors such as indoprofen are under investigation.
- Other names
- ICE(rel)IIICH-2TX
02
Mechanism of action
Inhibition of caspase-4 activity
03
Biological functions
PyroptosisInflammationInnate immunityCell deathCytokine processing
04
Disease associations
NeuroblastomaInfectionAutoinflammatory disorders
05
Safety considerations
Excessive inflammation due to dysregulated pyroptosis
06
Interacting drugs
Indoprofen
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