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Target intelligence / Profile preview
Caspase-6 (CASP6)
- Target
- CASP6
- Molecular classification
- Cysteine protease, Enzyme, Caspase
01
Overview
Caspase-6 is a cysteine-aspartic acid protease (caspase) enzyme that plays a central role in programmed cell death (apoptosis), immune responses, and homeostasis. It functions primarily as an executioner caspase during apoptosis but also has unique roles in innate immunity and neurodegenerative diseases. Specifically, it mediates inflammasome activation and promotes multiple programmed cell death pathways. Caspase-6 cleaves substrates like poly(ADP-ribose) polymerase and nuclear lamins, and is implicated in diseases such as Huntington’s and Alzheimer’s by cleaving HTT and APP, respectively. Its activity is tightly regulated by proteolytic processing and interactions within the caspase cascade.
- Other names
- Caspase 6CASP6 protein
02
Mechanism of action
Cleavage of target proteins involved in apoptosis, inflammation, and neurodegeneration.
03
Biological functions
ApoptosisInnate immunityInflammasome regulationNeurodegeneration mediatorCell death
04
Disease associations
Huntington's DiseaseAlzheimer's DiseaseParkinson's DiseaseLiver inflammationViral infection
05
Safety considerations
Potential for off-target effects due to broad substrate specificityDysregulation of apoptosis pathways
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