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Target intelligence / Profile preview
Caspase activity and apoptosis inhibitor 1 (CAAP1)
- Target
- CAAP1
- Molecular classification
- Other, Apoptosis regulator protein
01
Overview
Caspase activity and apoptosis inhibitor 1 (CAAP1) is an anti-apoptotic protein encoded by the human CAAP1 gene (also known as C9orf82). It localizes to mitochondria and regulates apoptosis by modulating the caspase-10-dependent mitochondrial caspase-3/9 feedback amplification loop, suppressing programmed cell death. CAAP1 has been reported to play roles in cancer biology, with decreased expression associated with increased platinum resistance in ovarian cancer, suggesting its potential as a biomarker and therapeutic target for diseases characterized by apoptosis dysregulation.
- Other names
- C9orf82CAAP1
02
Mechanism of action
Apoptosis inhibition via modulation of caspase-dependent pathways, regulation of mitochondrial apoptosis machinery
03
Biological functions
Apoptosis inhibitionRegulation of mitochondrial apoptosis pathwayNegative regulator of caspase-10 dependent mitochondrial caspase-3/9 amplification loopCell death modulation
04
Disease associations
Cancer (e.g., platinum resistance in ovarian cancer)Other diseases involving apoptosis dysregulation (potential, given function)
05
Safety considerations
Possible cancer resistance or survival effects if targeted inappropriately (inference based on anti-apoptotic role)so may contribute to drug resistance in oncology settings
06
Biomarkers
Potential biomarker for platinum resistance in ovarian cancer
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