Caspase recruitment domain-containing protein 10 (CARD10)

Caspase recruitment domain-containing protein 10 (CARD10) is a member of the CARD-CC protein family, acting as a scaffold protein that mediates activation of NF-κB signaling, typically via interactions with BCL10 or EGFR. CARD10 contains a caspase recruitment domain, a specialized protein-protein interaction module, and is also part of the membrane-associated guanylate kinase (MAGUK) family. Through its function, it participates in cellular signal transduction processes, is relevant in immune and inflammatory responses, and has been implicated in the pathogenesis of cancer and inflammatory diseases.

Other names

CARMA3Carma 3BIMP1CARD-containing MAGUK protein 3CARD-containing MAGUK 3 proteincaspase recruitment domain family member 10IMD89Bcl10 binding protein and activator of NFKB

Drugs targeting CARD10 (if any) would likely act through modulation of NF-κB signaling or inhibition of scaffolding interactions with BCL10 or EGFR