Caspase recruitment domain-containing protein 11 (CARD11)

Caspase recruitment domain-containing protein 11 (CARD11) is a large, multi-domain scaffold protein that belongs to the membrane-associated guanylate kinase (MAGUK) family. CARD11 is primarily expressed in hematopoietic cells, especially B and T lymphocytes, where it orchestrates crucial signaling pathways following antigen receptor engagement. Upon activation by kinases such as PKC, CARD11 undergoes conformational changes allowing it to recruit signaling partners BCL10 and MALT1—forming the CBM complex, which is essential for the activation of effector pathways like NF-κB, JNK, and mTOR. These signals direct lymphocyte activation, proliferation, differentiation, and survival, underpinning both normal and pathological adaptive immune responses. Mutations in CARD11 can lead to immunodeficiency, autoimmunity, lymphoproliferative disorders, and cancer, signifying its importance as a master regulator and a therapeutic target in immune-mediated diseases[1][2][3][4][5][6][7].

Other names

CARMA1BCL10-interacting MAGUK protein 3CARD-containing MAGUK protein 1BIMP3IMD11IMD11APPBL

Inhibition of CBM complex assembly. Inhibition of downstream signaling (NF-κB, JNK, mTOR). Modulation of protein-protein interactions (e.g., CARD11-BCL10 binding). Blocking phosphorylation or activation domains. Experimental approaches focus on interrupting scaffold assembly or oligomerization.