Caspase recruitment domain family member 16 (CARD16)

Caspase recruitment domain family member 16 (CARD16), commonly abbreviated as CARD16 or COP, is a regulatory protein belonging to the CARD-only proteins (COPs) with inhibitor functions for caspase-1 and caspase-4 activation. CARD16 regulates the proteolytic maturation and release of the pro-inflammatory cytokine interleukin-1 beta (IL-1β) in response to inflammatory stimuli, such as lipopolysaccharide, by controlling the assembly and activity of caspase-1 protein complexes. CARD16 can form oligomers that interact with caspase-1 and modulate cell death in multiple cell types, serving anti-apoptotic and anti-inflammatory roles. It participates in the regulation of signal transduction and gene expression related to inflammatory and stress responses. CARD16 also plays a role in disease, such as restraining apoptosis in cancer cells, contributing to inflammation, and buffering neuronal cells from death in neurodegenerative conditions like Huntington's disease.

Other names

COPCOP1Pseudo-ICEPseudo-IL1B-converting enzymeCaspase recruitment domain-containing protein 16CARD-only protein 1Caspase recruitment domain-only protein 1Caspase-1 inhibitor COPCaspase-1 dominant-negative inhibitor pseudo-ICELLID-114769

Inhibition of caspase-1 and caspase-4 activation, preventing cleavage of pro-IL-1β and downstream inflammation/apoptosis