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Target intelligence / Profile preview
Catalase-Peroxidase Enzyme (KatG)
- Target
- KatG
- Molecular classification
- Enzyme, Heme-dependent enzyme, Oxidoreductase
01
Overview
KatG is a bifunctional heme-dependent enzyme exhibiting both catalase and peroxidase activities. It is widely distributed among bacteria and lower eukaryotes, with particular significance in Mycobacterium tuberculosis, where it plays a crucial role in oxidative stress defense and antibiotic activation. It activates the antituberculosis prodrug isoniazid (INH) via its peroxidase activity. Mutations in the katG gene are a major mechanism of resistance to INH.
- Other names
- KatGCatalase-peroxidase
02
Mechanism of action
KatG activates isoniazid (INH) via its peroxidase activity. The activated drug then targets mycolic acid synthesis in the bacterial cell wall.
03
Biological functions
CatalysisReactive oxygen species detoxificationHydrogen peroxide decompositionPeroxidase activityDrug activation
04
Disease associations
InfectionTuberculosisDrug resistance
05
Safety considerations
Mutations in KatG lead to isoniazid resistance, a major challenge in TB treatment.Loss or mutation of KatG impairs INH activation.
06
Interacting drugs
Isoniazid (INH)
07
Biomarkers
KatG mutations (for isoniazid resistance)
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