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Target intelligence / Profile preview
Cathelicidin (CAMP)
- Target
- CAMP
- Molecular classification
- Antimicrobial peptide, Cationic peptide, Immune effector molecule
01
Overview
Cathelicidins are a family of antimicrobial peptides that play a crucial role in the innate immune system. In humans, the only known cathelicidin is LL-37, encoded by the CAMP gene. They exhibit broad-spectrum antimicrobial activity and also function in chemotaxis, angiogenesis, wound healing, and immune modulation. Dysregulation of cathelicidin expression is implicated in various diseases, including skin disorders and infections.
- Other names
- hCAP18LL-37CRAMP (mouse cathelicidin)FALL-39
02
Mechanism of action
Membrane disruption; pore formation; inhibition of protein/DNA synthesis
03
Biological functions
Antimicrobial activityChemotaxisAngiogenesisWound healingImmune modulationNeutrophil activationEndotoxin neutralization
04
Disease associations
InfectionInflammationSkin disorders (Atopic dermatitis, Psoriasis, Rosacea)Autoimmune diseases
05
Safety considerations
Overexpression may contribute to chronic inflammationPotential for off-target effects due to broad activity
06
Biomarkers
Cathelicidin levels in skin disordersCathelicidin levels as indicator of infection riskLL-37 concentration
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