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Target intelligence / Profile preview
Cathepsin B (CTSB)
- Target
- CTSB
- Molecular classification
- Enzyme, Protease, Cysteine protease, Papain-like cysteine protease
01
Overview
Cathepsin B is a lysosomal cysteine protease belonging to the papain family, encoded by the CTSB gene in humans. It plays a central role in intracellular protein catabolism and is involved in various physiological processes, including antigen processing for immune responses, hormone activation, bone turnover, and tissue remodeling. Cathepsin B also participates in apoptosis regulation and inflammatory responses. Elevated expression or mislocalization has been implicated in several diseases, most notably cancer, where it correlates with tumor invasiveness and metastasis. It is regulated by endogenous inhibitors such as Cystatin-B (CSTB).
02
Mechanism of action
Inhibition of Cathepsin B enzymatic activity
03
Biological functions
Protein degradationAntigen processingHormone processingApoptosis regulationBone turnoverInflammatory responseIntracellular protein catabolism
04
Disease associations
CancerChronic inflammatory diseasesPancreatitis
05
Safety considerations
Potential for off-target effects due to broad substrate specificityChallenges in achieving selective inhibition due to structural similarity with other cathepsinsPossible disruption of normal physiological processes involving Cathepsin B
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