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Target intelligence / Profile preview
Cathepsin C (CTSC)
- Target
- CTSC
- Molecular classification
- Enzyme, Lysosomal exo-cysteine protease, Peptidase C1 protein family, Cysteine cathepsin
01
Overview
Cathepsin C (CTSC), also known as dipeptidyl peptidase I (DPP-I), is a lysosomal exo-cysteine protease that plays a central role in activating serine proteases critical for immune cell function, particularly those involved in inflammation. It catalyzes the excision of dipeptides from the N-terminus of proteins and peptides and is implicated in various diseases, including inflammatory conditions and certain cancers. Inhibitors targeting cathepsin C are under clinical investigation for inflammatory conditions.
- Other names
- Dipeptidyl peptidase IDPP-I
02
Mechanism of action
Inhibition of Cathepsin C enzymatic activity
03
Biological functions
Activation of serine proteases in immunityActivation of serine proteases in inflammationExcision of dipeptides from protein/peptide N-terminals
04
Disease associations
Papillon-Lefèvre syndromeInflammatory diseasesBreast cancer metastasisNon-small cell lung cancer progression
05
Safety considerations
Potential for broad immune suppression if not selectively targeted
06
Interacting drugs
Brensocatib
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