Molecular Classification
Enzyme, Lysosomal exo-cysteine protease, Peptidase C1 protein family, Cysteine cathepsin
Other Names
Dipeptidyl peptidase I, DPP-I
Disease Roles
Papillon-Lefèvre syndromeInflammatory diseasesBreast cancer metastasis

Cathepsin C Overview

Cathepsin C (CTSC), also known as dipeptidyl peptidase I (DPP-I), is a lysosomal exo-cysteine protease that plays a central role in activating serine proteases critical for immune cell function, particularly those involved in inflammation. It catalyzes the excision of dipeptides from the N-terminus of proteins and peptides and is implicated in various diseases, including inflammatory conditions and certain cancers. Inhibitors targeting cathepsin C are under clinical investigation for inflammatory conditions.

Mechanism of Action

Inhibition of Cathepsin C enzymatic activity

Biological Functions

Activation of serine proteases in immunity
Activation of serine proteases in inflammation
Excision of dipeptides from protein/peptide N-terminals

Disease Associations

Papillon-Lefèvre syndrome
Inflammatory diseases
Breast cancer metastasis
Non-small cell lung cancer progression

Safety Considerations

  • Potential for broad immune suppression if not selectively targeted

Interacting Drugs

Brensocatib