Target intelligence / Profile preview

Cathepsin G

Molecular classification: Serine protease, Chymotrypsin family protease, Enzyme

Overview

Cathepsin G is a serine protease belonging to the chymotrypsin family, primarily expressed in neutrophils and mast cells. It plays a critical role in host defense through pathogen degradation and regulation of inflammation by modulating chemokines, cytokines, and the extracellular matrix. It has been implicated in various diseases including rheumatoid arthritis, cardiovascular disease, and cancer, making it a potential therapeutic target.

Other names: CTSGCG

Mechanism of action

Proteolytic cleavage of target proteins

Biological functions

Host defenseAntimicrobial activityRegulation of inflammationECM degradationAngiotensin processingPlatelet activation

Disease associations

Rheumatoid arthritisCoronary artery diseasePeriodontitisIschemic reperfusion injuryBone metastasisInfectious/inflammatory lung diseasesChronic postsurgical pain

Safety considerations

Potential for off-target effects due to broad substrate specificityCompromised host defense if inhibited excessively

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