Target intelligence / Profile preview

Cathepsin K (CTSK)

Target: CTSK
Molecular classification: Enzyme, Cysteine protease, Papain family protease

Overview

Cathepsin K (CTSK) is a lysosomal cysteine protease that belongs to the papain family. It is primarily expressed in osteoclasts and plays a crucial role in bone remodeling and resorption by degrading collagen and other matrix proteins. It has also been implicated in other biological processes, including thyroid hormone release and cancer progression, making it a therapeutic target for conditions like osteoporosis and certain cancers. Its activity can be stimulated by inflammatory cytokines.

Other names: Cathepsin O2CatK

Mechanism of action

Inhibition of Cathepsin K enzymatic activity, reducing bone resorption.

Biological functions

Bone resorptionExtracellular matrix degradationThyroid hormone releaseEndopeptidase activity

Disease associations

PycnodysostosisOsteoporosisArthritisAtherosclerosisCancer

Safety considerations

Increased risk of stroke (Odanacatib)Potential for off-target effects due to protease activity

Interacting drugs

Odanacatib

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