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Target intelligence / Profile preview
Cation-independent Mannose-6-Phosphate Receptor (CI-MPR)
- Target
- CI-MPR
- Molecular classification
- Receptor, Type I integral membrane protein
01
Overview
The cation-independent mannose-6-phosphate receptor (CI-MPR), also known as the insulin-like growth factor 2 receptor (IGF2R), is a large, multifunctional transmembrane glycoprotein that mediates the transport of phosphorylated lysosomal enzymes and binds IGF-II. It plays roles in intracellular trafficking, cellular signaling, and disease processes.
- Other names
- CI Man-6-P receptorIGF2RIGF-II receptorInsulin-like growth factor II receptorM6P/IGF2RMPRI
02
Mechanism of action
Mediates endocytosis and intracellular trafficking.
03
Biological functions
Trafficking of lysosomal enzymesMannose-6-phosphate recognitionIGF-II binding and clearanceCellular signaling
04
Disease associations
Lysosomal storage diseasesCancerNeurological disordersImmunological disorders
05
Safety considerations
Potential for off-target effects when used in therapeutic delivery systems.Altered expression or function may contribute to tumorigenesis.
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