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Cationic amino acid transporter 4 (CAT4)
- Target
- CAT4
- Molecular classification
- Transporter, Solute carrier family (SLC), Amino acid transporter
01
Overview
Cationic amino acid transporter 4 (CAT4), encoded by the SLC7A4 gene, is a member of the solute carrier family 7 that mediates the transport of cationic amino acids such as lysine, arginine, and ornithine across plasma membranes[1][3][7]. While the functional and structural profile is consistent with the SLC7 (solute carrier) transporter superfamily, its exact biological significance and transport activity in humans remain less fully characterized than other SLC7 family members. There are no approved drugs directly targeting SLC7A4 or well-established roles in major disease areas according to currently available resources[3][7].
- Other names
- SLC7A4CAT-4HCAT3VHsolute carrier family 7 member 4
02
Mechanism of action
Not established for drugs directly targeting this transporter; for the SLC7 family in general: inhibition or modulation of amino acid transport[7].
03
Biological functions
Transport of cationic amino acids across plasma membranesRegulation of amino acid homeostasis
04
Disease associations
Other (there is little direct evidence linking SLC7A4/CAT4 itself to specific disease states or strong associations with major disease classes; most research focuses on family or transporter system roles rather than confirmed direct links)
05
Safety considerations
None specific to CAT4/SLC7A4 documented; general considerations for targeting amino acid transporters include risk of altering cellular metabolic balance or affecting tissues dependent on cationic amino acid uptake.
06
Interacting drugs
None specifically listed as interacting with Cationic amino acid transporter 4 (CAT4/SLC7A4) in the referenced sources; related SLC family members have known interacting drugs but not this specific member[3][7].
07
Biomarkers
None established for SLC7A4/CAT4[3][7].
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