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Cationic Channel
- Molecular classification
- Ion Channel
01
Overview
Cationic channels are membrane proteins that facilitate the selective or non-selective passage of positively charged ions (cations) such as sodium (Na⁺), potassium (K⁺), calcium (Ca²⁺), and magnesium (Mg²⁺) across cellular membranes. These channels play essential roles in regulating membrane potential, signal transduction, muscle contraction, neuronal excitability, and various other physiological processes in both excitable cells (e.g., neurons, muscle cells) and non-excitable cells (e.g., lymphocytes, endothelial cells).
02
Mechanism of action
Pharmacological modulation with small molecules
03
Biological functions
Membrane potential regulationSignal transductionMuscle contractionNeuronal excitabilitySensory perceptionRegulation of heart rhythmIntracellular Ca²⁺ signaling
04
Disease associations
Cardiac arrhythmiasEpilepsyNeuropathiesKidney disordersFamilial focal segmental glomerulosclerosis
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