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Cationic Surfactant Membrane Disruption (Cetrimide)
- Molecular classification
- Quaternary Ammonium Compounds, Cationic Surfactants
01
Overview
Cetrimide is a cationic surfactant mixture, primarily composed of tetradecyltrimethylammonium bromide (TTAB), cetrimonium bromide (CTAB), and laurtrimonium bromide (DTAB). It acts by disrupting microbial cell membranes through electrostatic interactions with negatively charged components, leading to increased permeability and cell death. It is used as an antiseptic/disinfectant in wound cleaning and topical formulations and has experimental uses in inhibiting endocytosis.
- Other names
- CetrimideTetradecyltrimethylammonium bromideTTABMiTMABCetrimonium bromideCTABLaurtrimonium bromideDTABLTAB
02
Mechanism of action
Disrupts microbial membranes via electrostatic interaction with phospholipids, leading to increased membrane permeability and cell death.
03
Biological functions
AntisepticDisinfectantMembrane disruptionEndocytosis inhibition (experimental)
04
Disease associations
Infection
05
Safety considerations
Skin corrosion/irritationEye damageHarmful if swallowedPotential for resistance development
06
Interacting drugs
Savlon (component)
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