Caveolae-associated protein 3 (CAVIN3)

Caveolae-associated protein 3 (CAVIN3), also known as SRBC or PRKCDBP, is an adapter and structural protein critical for the formation and function of caveolae—small, flask-shaped invaginations of the plasma membrane involved in signal transduction and membrane trafficking. CAVIN3 is part of the cavin protein family (which includes CAVIN1, CAVIN2, and CAVIN4), and helps link signaling molecules such as protein kinase C (PKC) to membrane compartments for signal regulation. CAVIN3 is frequently epigenetically silenced in diverse cancers via promoter methylation, and its loss impairs apoptosis and DNA repair, partly by directly interacting with BRCA1 and influencing homologous recombination DNA repair pathways. CAVIN3-deficient cells are more sensitive to PARP inhibition and display increased genomic instability, highlighting its tumor suppressor role and potential as a biomarker for cancer diagnosis, prognosis, and therapy stratification. No direct drug interactions or therapies targeting CAVIN3 have been described, but loss of function may inform the use of DNA repair-targeting drugs such as PARP inhibitors in oncology.

Other names

CAVIN3PRKCDBPSRBChSRBCcavin-3Protein kinase C delta-binding proteinSerum deprivation response factor-related gene product that binds to C-kinasesdr-related gene product that binds to c-kinaseMGC20400

Modulation of DNA repair pathways (e.g. BRCA1-dependent homologous recombination); Sensitization to PARP inhibitors when CAVIN3 is deleted; Not a direct drug target currently