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Target intelligence / Profile preview
Caveolae-associated protein 4 (CAVIN4)
- Target
- CAVIN4
- Molecular classification
- Other (caveolar structural/scaffold protein)
01
Overview
Caveolae-associated protein 4 (CAVIN4 or MURC) is a muscle-specific structural protein found in the caveolae and T-tubules of cardiomyocytes. While it is not essential for caveola formation, CAVIN4 modulates caveolar morphology and serves as a scaffold for ERK1/2, facilitating their recruitment and activation in response to α1-adrenergic receptor signaling. CAVIN4 also promotes Rho/ROCK pathway activation and supports myofibrillar organization. Mutations or dysregulation of CAVIN4 are associated with several cardiac conditions, including hypertrophy and inherited cardiomyopathies[1][2][5][6].
- Other names
- Muscle-restricted coiled-coil proteinMURCcavin-4muscle-related coiled-coil protein
02
Biological functions
Modulates caveolar morphology in cardiomyocytesFacilitates recruitment of MAPK1/3 (ERK1/2) to caveolaePromotes Rho/ROCK (Rho-kinase) signalingSupports myofibrillar organizationRegulates α1-adrenergic receptor-induced hypertrophic responses in cardiomyocytes
03
Disease associations
Cardiovascular disease (e.g., cardiac hypertrophy, dilated cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, atrial fibrillation)
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