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Target intelligence / Profile preview
Caveolin-1 Scaffolding Domain (CSD)
- Target
- CSD
- Molecular classification
- Protein Domain, Scaffolding Protein
01
Overview
The caveolin-1 scaffolding domain (CSD) is a 20-amino acid sequence (residues 82–101) within the caveolin-1 (Cav-1) protein. It mediates interactions between Cav‑1 and various signaling proteins by binding to caveolin-binding motifs (CBMs), regulating multiple cellular processes. Synthetic peptides mimicking the CSD have therapeutic potential in treating fibrosis, inflammation, and aging-related organ dysfunction.
- Other names
- Cav-1 Scaffolding DomainCaveolin Scaffolding DomainCSD peptide
02
Mechanism of action
Mimicking the CSD with synthetic peptides can restore HO-1 activity, block lung fibrosis progression, suppress tissue edema and vascular leakage, and reverse aging-associated fibrosis and microvascular leakage.
03
Biological functions
Signal transductionEnzyme inhibitionProtein-protein interactionRegulation of membrane dynamics
04
Disease associations
FibrosisInflammationVascular permeabilityAging-related organ dysfunction
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