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CBLL1 antisense RNA 1 (CBLL1-AS1)

Target: CBLL1-AS1
Molecular classification: lncRNA, Non-coding RNA

Overview

CBLL1 antisense RNA 1 (CBLL1-AS1) is a long non-coding RNA transcribed from the antisense strand of the CBLL1 gene locus. Antisense RNAs like CBLL1-AS1 are often implicated in regulating their associated sense gene at the level of transcription, splicing, or translation, potentially affecting the protein product's abundance or activity. Dysregulation of antisense RNAs and their target genes is a recognized mechanism in cancer and other diseases, though no specific disease association or direct therapeutic targeting of CBLL1-AS1 is currently described. CBLL1 itself is a well-characterized E3 ubiquitin ligase involved in the ubiquitination and endocytosis of E-cadherin and is connected to cancer cell signaling[4][5].

Other names: CBLL1-AS1

Mechanism of action

Not established (No drugs directly target this lncRNA in clinical or experimental use.)

Biological functions

Potential regulator of gene expression impacting the CBLL1 geneMay be involved in RNA modification or regulation of ubiquitination through effects on CBLL1 protein expressionGeneral regulatory lncRNA function in cellular processes

Disease associations

Potential roles in cancer biology are suspected, as lncRNAs are often implicated in cancer progression via epigenetic regulation, but there are no direct results attributing disease roles to CBLL1-AS1 specifically in the sources provided.Related to CBLL1 function, which is associated with Wilms tumor 1 and diffuse gastric and lobular breast cancer syndrome

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