CBY1-interacting BAR domain-containing protein 2 (CIBAR2)

CBY1-interacting BAR domain-containing protein 2 (CIBAR2), also known as FAM92B, is a membrane-associated protein containing a BAR (Bin/Amphiphysin/Rvs)-domain. It is implicated in the regulation of cilium assembly (ciliogenesis) and is predicted to localize to cellular structures such as the centriole, ciliary basal body, and ciliary transition zone[5][7][10]. CIBAR2 interacts with CBY1 and is thought to facilitate ciliogenesis, likely by aiding the recruitment and fusion of endosomal vesicles at distal appendages during the early stages of ciliary formation[5][6]. Although structurally closely related to FAM92A (CIBAR1) and capable of forming homodimers and potentially heterodimers, the exact molecular mechanisms and broader cellular roles of CIBAR2 remain poorly defined[2]. Current data do not support CIBAR2 as a recognized therapeutic target or as having known pharmacological modulators. Familial and sequence similarity as well as functional analogies suggest a role in diseases linked to ciliary dysfunction, including inflammatory bowel disease and nephronophthisis[5]. There are no known interacting drugs, biomarker roles, or specific safety concerns reported for this protein to date.

Other names

FAM92BProtein FAM92BFLJ44299family with sequence similarity 92 member BCBY1 interacting BAR domain containing 2