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CCDC28A antisense RNA 1 (CCDC28A-AS1)

Target
CCDC28A-AS1
Molecular classification
Long non-coding RNA (lncRNA), Antisense RNA, Other
01

Overview

CCDC28A antisense RNA 1 is a long non-coding antisense RNA transcribed from the opposite strand of the CCDC28A locus, affiliated with the lncRNA gene class. It may participate in the regulation of its sense gene, CCDC28A, or exhibit functions typical of antisense RNAs, such as modulating transcription, splicing, or RNA stability, but its biological and clinical significance remain largely uncharacterized[1][2][3][6]. Although there are references to "Putative uncharacterized protein CCDC28A-AS1," current evidence primarily supports its role as a non-coding RNA, not a protein-coding gene. There is confusion with the related protein-coding gene CCDC28A, which is involved in fusion events in leukemia, but CCDC28A-AS1 by itself is not an established therapeutic target, receptor, or drug-interaction molecule.\n\nNote:\n- The term "GVQW motif-containing protein 2" and references to a protein product are more accurately associated with the protein-coding gene CCDC28A or its fusion variants, not CCDC28A-AS1, which is classified as lncRNA[3][5][7].\n- This entry is likely incorrect for drug development targeting or therapeutic categorization purposes due to its nature as a non-coding RNA and lack of functional or disease-specific data.

Other names
CCDC28A-AS1GVQW2GVQW motif-containing protein 2GVQW motif containing 2Putative uncharacterized protein CCDC28A-AS1protein GVQW2
02

Biological functions

Alternative splicingRNA bindingRegulation of sense gene expression (by antisense interaction with CCDC28A)
03

Disease associations

Other (no direct association with well-characterized diseases established; related protein-coding gene CCDC28A is involved in leukemia via fusion with NUP98, but CCDC28A-AS1’s disease relevance remains unclear)

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