CCR4-NOT transcription complex subunit 1 (CNOT1)

CCR4-NOT transcription complex subunit 1 (CNOT1) is the largest subunit of the conserved CCR4-NOT complex, acting as a central scaffolding protein that assembles and stabilizes the other subunits of this multi-protein complex[1][2][3][6]. CNOT1 itself does not have enzymatic or receptor activity, but is essential for deadenylase activity and mRNA decay by recruiting deadenylase modules, such as CNOT7/8 and CNOT6/6L, which are responsible for shortening the poly(A) tails of mRNAs, a key step in regulated mRNA turnover[1][3][6]. CNOT1 also regulates transcription, including by repressing ligand-dependent nuclear receptor signaling (such as estrogen receptor alpha and retinoid X receptor), and interacts with specific RNA-binding proteins to direct mRNA specificity under physiological and developmental contexts[1][5]. CNOT1 is requisite for cellular homeostasis; its depletion destabilizes the entire CCR4-NOT complex and can lead to apoptosis, developmental defects, and deregulation of genes involved in cell proliferation and cancer[1][5].\n\nNote:\n- CNOT1 is not a receptor, enzyme, or transporter itself; it is not a direct drug target, but rather a scaffolding and regulatory component of a major gene expression control complex[1][2][3][6].\n- There are currently no clinically used drugs or known small-molecule modulators that directly target CNOT1; reported disease roles are primarily due to dysregulation or aberrant function within the complex, especially in cancer and cell fate determination[1][5].\n- CNOT1 may serve as a platform for regulatory protein interactions, and its loss or mutation affects mRNA stability and gene expression critical in disease states[1][2][5].

Other names

CCR4-NOT transcription complex subunit 1CNOT1CDC39KIAA1007NOT1AD-005NOT1HhNOT1HPE12VIBOSCCR4-associated factor 1Negative regulator of transcription subunit 1 homologadrenal gland protein AD-005NOT1 (negative regulator of transcription 1, yeast) homolog