CCR4-NOT transcription complex subunit 4 (CNOT4)

CCR4-NOT transcription complex subunit 4 (CNOT4) is a protein component of the highly conserved, multifunctional CCR4-NOT complex, which acts as a major regulator of mRNA metabolism and gene expression in eukaryotic cells[1][2][3]. The CCR4-NOT complex is involved in various aspects of mRNA processing and decay, specifically catalyzing deadenylation (the shortening of poly(A) tails), thereby marking mRNA for degradation and regulating translation[1][2][3]. CNOT4, as part of this multiprotein complex, also participates in transcriptional regulation, protein ubiquitination, chromatin modification, and cellular quality control mechanisms[1][2][3]. Disruption of CCR4-NOT complex function, including that of CNOT4, can impact cell cycle regulation, DNA repair, and may be associated with diseases such as cancer and neurodegenerative disorders[3]. CNOT4 is not considered a direct therapeutic target or receptor but is essential for cellular homeostasis due to its role in post-transcriptional and transcriptional regulation[3].

Other names

CCR4-NOT complex subunit 4Component of CCR4-NOT complexCNOT4 (canonical abbreviation)Negative on TATA-less 4