CCR4-NOT transcription complex subunit 6-like (CNOT6L)

CCR4-NOT transcription complex subunit 6-like (CNOT6L) is a ubiquitously expressed poly(A)-specific ribonuclease enzyme and member of the EEP superfamily, serving as a core catalytic subunit of the multimeric CCR4-NOT transcription complex. CNOT6L catalyzes magnesium-dependent deadenylation, acting mainly in the cytoplasm to shorten the poly(A) tails of specific mRNAs, thus regulating their stability and controlling gene expression at the post-transcriptional level. Its activity directly impacts cell proliferation, cell cycle progression, and tumor suppressor functions. Structurally, CNOT6L has a C-terminal nuclease domain and an N-terminal leucine-rich repeat domain, with the former responsible for strict poly(A) RNA specificity. CNOT6L’s mRNA also encodes stable circular RNA (circCNOT6L), linked to certain cancer phenotypes. Human CNOT6L is functionally distinct from its paralog CNOT6 and is essential for efficient cell growth, with unique tissue distribution and biological effects, particularly in cancer biology[1][2][3][4][5].

Other names

CNOT6LCCR4BCcr4bCarbon catabolite repressor protein 4 homolog BDKFZp434K098CCR4-NOT transcription complex subunit 6-likeCCR4b

No known drugs target CNOT6L directly, so mechanism for drug action is not established. If targeted by inhibitors or RNA-based therapeutics, the likely mechanism would be inhibition or knockdown of its mRNA-deadenylase activity, affecting mRNA stability and, subsequently, cellular proliferation.