CCR4-NOT transcription complex subunit 8 (CNOT8)

CCR4-NOT transcription complex subunit 8 (CNOT8) is an enzymatic component of the multi-subunit CCR4-NOT complex, serving as a poly(A)-specific 3'-5' exoribonuclease (deadenylase)[1][2][6]. CNOT8 regulates mRNA turnover by shortening poly(A) tails, facilitating mRNA decay, and thus modulating the abundance, stability, and translational efficiency of key transcripts[1][5][3]. It is crucial for post-transcriptional gene silencing, including miRNA-mediated gene regulation, and is essential for processes such as cell proliferation, embryonic development, and pluripotency state transitions[2][3][6][7]. CNOT8 shows partly redundant functions with its paralog CNOT7, but is indispensable for viability in both mouse and human cells, underscoring its core role in gene expression control[7][1]. Disruption of CNOT8 destabilizes cellular transcriptomes, can cause embryonic lethality in mice, and is associated with biological phenomena including cancer progression and developmental disorders[3][7][2]. CNOT8 is not currently considered a direct therapeutic target and is not associated with known small-molecule drugs or clinically used inhibitors, but its central regulatory function may make it of interest for future disease-modifying interventions targeting abnormal mRNA turnover.

Other names

Caf1bHCAF1CALIFPOP2CAF1hCAF1CAF1-like proteinCAF2CCR4-associated factor 8CALIFpPGK promoter directed over production