Molecular Classification
Poliovirus receptor (PVR) family, Nectin and nectin-like family, Single-pass transmembrane protein, Receptor
Other Names
PVRIG, Poliovirus Receptor Related Immunoglobulin Domain Protein
Disease Roles
CancerImmunosuppression

CD112 receptor Overview

CD112R is a co-inhibitory immune checkpoint receptor preferentially expressed on immune cells, especially NK cells, NKT cells, and T cells. Its primary ligand is CD112 (Nectin-2). CD112R inhibits T cell receptor–mediated signaling, leading to reduced cytokine production and proliferation in T cells. Targeting the CD112R–CD112 axis can enhance anti-tumor immunity, making it a potential target for cancer immunotherapy.

Mechanism of Action

Checkpoint blockade; disruption of CD112R-CD112 interaction enhances anti-tumor immunity

Biological Functions

Immune checkpoint
Inhibits T cell receptor–mediated signaling
Suppresses T-cell activation
Modulates immune responses

Disease Associations

Cancer
Immunosuppression

Safety Considerations

No safety concerns listed