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Target intelligence / Profile preview
CD112 receptor (CD112R)
- Target
- CD112R
- Molecular classification
- Poliovirus receptor (PVR) family, Nectin and nectin-like family, Single-pass transmembrane protein, Receptor
01
Overview
CD112R is a co-inhibitory immune checkpoint receptor preferentially expressed on immune cells, especially NK cells, NKT cells, and T cells. Its primary ligand is CD112 (Nectin-2). CD112R inhibits T cell receptor–mediated signaling, leading to reduced cytokine production and proliferation in T cells. Targeting the CD112R–CD112 axis can enhance anti-tumor immunity, making it a potential target for cancer immunotherapy.
- Other names
- PVRIGPoliovirus Receptor Related Immunoglobulin Domain Protein
02
Mechanism of action
Checkpoint blockade; disruption of CD112R-CD112 interaction enhances anti-tumor immunity
03
Biological functions
Immune checkpointInhibits T cell receptor–mediated signalingSuppresses T-cell activationModulates immune responses
04
Disease associations
CancerImmunosuppression
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