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Target intelligence / Profile preview
Monocyte differentiation antigen CD14 (CD14)
- Target
- CD14
- Molecular classification
- Pattern Recognition Receptor (PRR), Glycoprotein, Leucine-rich repeat protein
01
Overview
Monocyte differentiation antigen CD14 is an essential pattern recognition receptor predominantly found on myeloid cells. It detects bacterial components—especially LPS—and initiates innate immune responses through cooperation with TLR4. Its unique GPI-anchor distinguishes it structurally from many other membrane receptors. Both its membrane-bound and soluble forms are functionally significant for host defense against infection.
- Other names
- Myeloid cell-specific leucine-rich glycoproteinCD14 antigen
02
Mechanism of action
CD14 acts as a co-receptor with TLR4 and MD2 to detect LPS and other PAMPs, triggering intracellular signaling cascades and proinflammatory cytokine production.
03
Biological functions
Innate immune responseLPS recognitionCo-receptor signaling with TLR4/MD2Cytokine productionPathogen recognition
04
Disease associations
SepsisInflammationInfectionParoxysmal nocturnal hemoglobinuria
05
Safety considerations
Overactivation of CD14 can lead to excessive inflammatory responses and sepsis.Therapeutic targeting of CD14 may require careful modulation to avoid immunosuppression.
06
Biomarkers
CD14 expression levels can be used to identify monocyte subsets.sCD14 levels in serum can be indicative of immune activation or inflammation.
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