Target intelligence / Profile preview

Melanoma Cell Adhesion Molecule (MCAM)

Target: MCAM
Molecular classification: Single-pass transmembrane glycoprotein, Cell adhesion molecule

Overview

Melanoma Cell Adhesion Molecule (MCAM), also known as MUC18 or CD146, is a single-pass transmembrane glycoprotein involved in cell adhesion, endothelial cohesion, and signal transduction. It plays a role in angiogenesis, wound healing, and hematopoiesis regulation. MCAM is implicated in melanoma progression and metastasis, and serves as a biomarker for COPD and uveal melanoma. It exists in long, short, and soluble isoforms.

Other names: MUC18CD146

Biological functions

Cell adhesionEndothelial cohesionSignal transductionAngiogenesisWound healingHematopoiesis regulation

Disease associations

MelanomaEpithelioid Trophoblastic TumorChronic Obstructive Pulmonary Disease (COPD)Uveal Melanoma

Biomarkers

COPDUveal Melanoma

Beyond the preview

Go deeper on Melanoma Cell Adhesion Molecule (MCAM).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Melanoma Cell Adhesion Molecule (MCAM).

Explore the full profile