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Target intelligence / Profile preview
CD146 antigen (CD146)
- Target
- CD146
- Molecular classification
- Cell adhesion molecule, Immunoglobulin superfamily, Type I transmembrane protein
01
Overview
CD146 antigen (MCAM) is a cell adhesion molecule belonging to the immunoglobulin superfamily. It is a transmembrane glycoprotein involved in cell adhesion, endothelial cell function, angiogenesis, and metastasis. It is highly expressed in melanoma and sarcoma, making it a diagnostic marker and potential therapeutic target.
- Other names
- MCAMMelanoma Cell Adhesion MoleculeMUC18S-Endo1Endo-CAMMel-CAM
02
Mechanism of action
Monoclonal antibodies against CD146 can inhibit its function or be used for targeted drug delivery. Soluble CD146 can modulate gene transcription.
03
Biological functions
Cell adhesionEndothelial intercellular junction stabilizationRegulation of endothelial cell motilityAngiogenesis regulationMetastasis
04
Disease associations
CancerMelanomaSarcomaVascular diseases
05
Safety considerations
Potential for off-target effects due to expression on normal tissues, especially endotheliumImmunogenicity of monoclonal antibodies
06
Biomarkers
CD146 expression levels in tumor tissue
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