Target intelligence / Profile preview

CD147 antigen (CD147)

Target: CD147
Molecular classification: Type I transmembrane glycoprotein, Immunoglobulin superfamily

Overview

CD147, also known as basigin or EMMPRIN, is a transmembrane glycoprotein involved in various biological processes including development, immune regulation, extracellular matrix remodeling, metabolic transport, cancer progression, and infectious disease. It is considered a therapeutic target in cancer and infectious diseases.

Other names: BasiginEMMPRINExtracellular matrix metalloproteinase inducerHAb18GM6 antigenOK blood group antigenTumor cell-derived collagenase stimulatory factor (TCSF)NeurothelinOX475A11/5F7/CE9

Mechanism of action

Monoclonal antibodies targeting CD147 can inhibit its function in promoting tumor growth, metastasis, and viral entry.

Biological functions

Fetal developmentNeural network formationSpermatogenesisEmbryo implantationT cell activation modulationCytokine production regulationExtracellular matrix remodelingMetabolic transport facilitationAngiogenesisCell proliferationInvasion/metastasis

Disease associations

CancerMalariaCOVID-19Inflammation

Safety considerations

Potential for off-target effects due to widespread expression of CD147.Limited data on long-term safety of CD147-targeted therapies.

Biomarkers

CD147 expression levels in tumors can be a biomarker for aggressiveness and prognosis.

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