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Target intelligence / Profile preview
CD15 Antigen (CD15)
- Target
- CD15
- Molecular classification
- Carbohydrate epitope, Glycolipid, Glycoprotein
01
Overview
CD15 antigen, also known as Lewis x (Le^x), X-hapten, or stage-specific embryonic antigen-1 (SSEA-1), is a carbohydrate epitope with the structure 3-fucosyl-N-acetyllactosamine. This trisaccharide determinant is present on various glycolipids and glycoproteins at the cell membrane. It plays roles in immune functions like phagocytosis, chemotaxis, and leukocyte trafficking. Clinically, it is primarily used as a diagnostic marker for Hodgkin lymphoma.
- Other names
- Lewis x Blood Group antigenLe(x)SSEA-1X-hapten3-fucosyl-N-acetyllactosamine
02
Biological functions
PhagocytosisBactericidal activityChemotaxisCell-cell interactionsDegranulationRespiratory burstProinflammatory signalingLeukocyte trafficking
03
Disease associations
Hodgkin lymphomaLeukemiaLymphomaInflammation
04
Biomarkers
Hodgkin lymphoma diagnosis
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