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Target intelligence / Profile preview
Fc gamma receptor III (CD16)
- Target
- CD16
- Molecular classification
- Receptor
01
Overview
Fc gamma receptor III (FcγRIII), also known as CD16, is a low-affinity receptor for the Fc portion of immunoglobulin G (IgG). It plays a crucial role in immune system activation and regulation, particularly in processes such as antibody-dependent cellular cytotoxicity (ADCC), phagocytosis, degranulation, and cytokine release.
- Other names
- FcγRIIICD16aCD16bLow Affinity Immunoglobulin Gamma Fc Region Receptor III-ALow Affinity Immunoglobulin Gamma Fc Region Receptor III-BFcgammaRIIIAFcgammaRIIIBNeutrophil-Specific Antigen NA
02
Mechanism of action
Engagement with IgG leads to clustering/activation that triggers downstream signaling cascades through associated γ-chains containing ITAM motifs. This results in cellular activation events including ADCC or cytokine secretion depending on cell type involved
03
Biological functions
Antibody-dependent cellular cytotoxicity (ADCC)PhagocytosisDegranulationCytokine releaseImmune response
04
Disease associations
Autoimmune diseasesInfectionCancer
05
Safety considerations
Polymorphisms within FCGR3A/B genes can affect binding affinity for IgG subclasses and influence clinical responses to therapeutic monoclonal antibodies.
06
Interacting drugs
Therapeutic monoclonal antibodies
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