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Target intelligence / Profile preview
CD19 (B lymphocyte antigen) (CD19)
- Target
- CD19
- Molecular classification
- Type I transmembrane glycoprotein, Receptor, B-cell marker
01
Overview
CD19, also known as B-lymphocyte antigen CD19, is a transmembrane glycoprotein and a key biomarker for B cell lineage. It is expressed throughout most stages of B cell development and functions as a coreceptor with the B-cell receptor complex (BCR), primarily functioning to lower the threshold for activation of the BCR signaling pathway. It is a therapeutic target for monoclonal antibodies and CAR-T therapies in hematologic malignancies.
- Other names
- B-Lymphocyte Surface Antigen B4T-Cell Surface Antigen Leu-12CVID3Cluster of Differentiation 19
02
Mechanism of action
Antibody-dependent cell-mediated cytotoxicity (ADCC) for monoclonal antibodies; T-cell mediated cytotoxicity for CAR-T therapies targeting CD19.
03
Biological functions
Signal transductionImmune responseB-cell activationB-cell proliferationB-cell differentiationImmune regulationBCR signaling
04
Disease associations
LeukemiaLymphomaAutoimmunity
05
Safety considerations
Cytokine release syndrome (CRS) with CAR-T therapyOn-target, off-tumor toxicityB-cell aplasia
06
Interacting drugs
Monoclonal antibodies targeting CD19
1 more in the full profile.
07
Biomarkers
Presence of CD19 on B cells in leukemia/lymphomaCD19 expression levels for CAR-T cell therapy response prediction
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