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Target intelligence / Profile preview
CD19 Antigen (CD19)
- Target
- CD19
- Molecular classification
- Type I transmembrane glycoprotein, Immunoglobulin superfamily, Receptor
01
Overview
CD19 antigen is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily, primarily expressed on B lymphocytes throughout most stages of their development. It serves as a critical biomarker for B cell lineage and is widely used in clinical diagnostics and targeted therapies, especially for hematological malignancies such as leukemia and lymphoma.
- Other names
- B-Lymphocyte Surface Antigen B4T-cell surface antigen Leu‑12Differentiation antigen CD19CVID3
02
Mechanism of action
Anti-CD19 antibodies induce apoptosis or immune-mediated killing. CAR-T therapy redirects T cells to kill CD19-expressing cells.
03
Biological functions
Signal transductionImmune responseB cell developmentLymphocyte activationCell proliferationCell differentiation
04
Disease associations
CancerAutoimmune disorder
05
Safety considerations
Cytokine release syndrome (CRS) in CAR-T therapyOn-target, off-tumor toxicity affecting normal B cellsB cell aplasia
06
Interacting drugs
Anti-CD19 monoclonal antibodies
1 more in the full profile.
07
Biomarkers
CD19 expression levels for patient selection in CAR-T therapyCD19 expression levels for monitoring treatment efficacy in B-cell malignancies
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