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Target intelligence / Profile preview
CD1d-presented Glycolipid
- Molecular classification
- Glycolipid, Antigen, MHC-like molecule ligand
01
Overview
CD1d-presented glycolipids are a class of antigens recognized by invariant natural killer T (iNKT) cells. These glycolipids are presented on the cell surface by the non-polymorphic, MHC class I-like molecule CD1d. The interaction between CD1d-glycolipid complexes and iNKT cell receptors is central to the activation of iNKT cells and subsequent immune modulation.
- Other names
- CD1d-glycolipid complexGlycolipid antigen presented by CD1dCD1d-lipid antigenCD1d-restricted antigen
02
Mechanism of action
Activation of iNKT cells via CD1d presentation leading to cytokine release and immune modulation
03
Biological functions
Immune activationAntigen presentationT cell activationCytokine productionImmune modulationInnate immunityAdaptive immunity
04
Disease associations
CancerInfectionAutoimmunityInflammation
05
Safety considerations
Potential for cytokine stormOff-target effects on other immune cellsAutoimmune reactionsTolerance induction
06
Interacting drugs
alpha-Galactosylceramide (α-GalCer)
1 more in the full profile.
07
Biomarkers
iNKT cell activationCytokine levels (IFN-γ, IL-4)CD1d expressionGlycolipid-specific T cell responses
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