Molecular Classification
Glycolipid, Antigen, MHC-like molecule ligand
Other Names
CD1d-glycolipid complex, Glycolipid antigen presented by CD1d, CD1d-lipid antigen, CD1d-restricted antigen
Disease Roles
CancerInfectionAutoimmunity

CD1d-presented Glycolipid Overview

CD1d-presented glycolipids are a class of antigens recognized by invariant natural killer T (iNKT) cells. These glycolipids are presented on the cell surface by the non-polymorphic, MHC class I-like molecule CD1d. The interaction between CD1d-glycolipid complexes and iNKT cell receptors is central to the activation of iNKT cells and subsequent immune modulation.

Mechanism of Action

Activation of iNKT cells via CD1d presentation leading to cytokine release and immune modulation

Biological Functions

Immune activation
Antigen presentation
T cell activation
Cytokine production
Immune modulation
Innate immunity
Adaptive immunity

Disease Associations

Cancer
Infection
Autoimmunity
Inflammation

Safety Considerations

  • Potential for cytokine storm
  • Off-target effects on other immune cells
  • Autoimmune reactions
  • Tolerance induction

Interacting Drugs

alpha-Galactosylceramide (α-GalCer)
Synthetic glycolipid analogues

Associated Biomarkers

Biomarker
iNKT cell activation
Cytokine levels (IFN-γ, IL-4)
CD1d expression
Glycolipid-specific T cell responses