CD2-associated protein (CD2AP)

CD2-associated protein (CD2AP) is a cytoplasmic adaptor protein involved in the regulation of the actin cytoskeleton and organization of cell membrane proteins[1][2][3][5]. It contains multiple SH3 domains and a proline-rich region, mediating direct interaction with filamentous actin and other proteins at cell–cell junctions, notably in podocyte slit diaphragms in the kidney[1][5][6]. CD2AP is critical for glomerular filtration barrier integrity; haploinsufficiency or mutation leads to glomerular disease and severe proteinuria[1][2][5]. CD2AP is also expressed in immune cells, neurons, and epithelial cells, where it contributes to intracellular signaling, immune synapse formation, and endocytic vesicle trafficking[2][4][5]. In the nervous system, CD2AP regulates synaptic structure, plasticity, and protein turnover, and genetic variation at the CD2AP locus increases Alzheimer’s disease risk[2][4]. To date, no drugs directly target CD2AP, and it is not considered a therapeutic receptor, enzyme, transporter, or ion channel; rather, it is classified as an adaptor/scaffold protein[1][5].

Other names

CD2APCMSAdapter protein CMSCas ligand with multiple SH3 domainsCas ligand with multiple Src homology 3 domains

Not applicable (no direct drug targeting established)