CD2-binding protein 2 (CD2BP2)

CD2-binding protein 2 is an adaptor protein and essential component of the spliceosome, particularly the U5 small nuclear ribonucleoprotein (snRNP) complex, involved in the precise excision of introns from pre-mRNA. It contains a conserved GYF domain mediating specific protein-protein interactions[1][3]. While originally identified as a binding partner of the CD2 T-cell surface antigen (implicating a minor role in T cell signaling), its critical cellular function is in the nucleus, enabling accurate mRNA splicing and microRNA stability. Loss of CD2BP2 impairs T cell development through altered splicing of transcripts controlling proliferation and apoptosis[3]. Alternative and divergent transcript variants are predicted but not characterized for biological activity or therapeutic relevance[1]. "CD2BP2 divergent transcript" (CD2BP2-DT) likely refers to an uncharacterized alternative transcript, not an established protein or therapeutic target. For structured data, use the well-characterized “CD2-binding protein 2 (CD2BP2)” as the canonical entry. Alternative transcripts remain to be experimentally validated for function[1][3].

Other names

SNU40U5-52KLIN1FWP010PPP1R59

Not applicable.