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Target intelligence / Profile preview
CD20 antigen (CD20)
- Target
- CD20
- Molecular classification
- Membrane protein, Transmembrane protein, Membrane-spanning 4A gene family (MS4A)
01
Overview
CD20, also known as B-lymphocyte antigen CD20, is a non-glycosylated transmembrane protein expressed on the surface of B cells from the pre-B cell stage through maturity. It acts as a membrane-bound calcium channel involved in Ca²⁺ influx during B-cell activation and regulates nanoscale organization of receptors on resting B lymphocytes. CD20 is widely used as a therapeutic target for hematologic malignancies and autoimmune diseases, with therapies including monoclonal antibodies like rituximab that bind to CD20-positive B-cells leading to their depletion.
- Other names
- B-lymphocyte antigen CD20MS4A1
02
Mechanism of action
Monoclonal antibodies bind to CD20-positive B-cells leading to their depletion by immune-mediated mechanisms
03
Biological functions
Calcium channel activityB-cell activationB-cell developmentB-cell differentiationReceptor organizationSignal transduction
04
Disease associations
Hematologic malignanciesNon-Hodgkin lymphomaChronic lymphocytic leukemiaAutoimmune diseasesRheumatoid arthritisMultiple sclerosisImmunodeficiencies
05
Safety considerations
Immune-mediated side effectsLong-term effects of B-cell depletionResistance mechanisms
06
Interacting drugs
Rituximab
07
Biomarkers
CD20 expression levels for diagnosis and monitoring response to anti-CD20 agents
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